The impact of the variant on RNA or protein purpose, determined by experimental proof from submitters.

This price is calculated by NCBI based on knowledge from submitters. Browse our policies for calculating the critique position. The volume of submissions which add to this evaluate position is demonstrated in parentheses.

There is no useful evidence in ClinVar for this variation. For those who have produced useful info for this variation, you should think about submitting that details to ClinVar.

This column incorporates more info supporting the classification, including citations, the comment on classification, and thorough proof supplied as observations with the variant from the submitter.

The issue with the classification, provided by the submitter for this submitted (SCV) document. This column also incorporates the impacted status and allele origin of individuals noticed with this particular variant.

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There won't be any citations for germline classification of the variant in ClinVar. If you are aware of of citations for this variation, you should take into account submitting that information and facts to ClinVar.

The publishing Group for this submitted (SCV) file. This column also incorporates the SCV accession and Variation range, the date this SCV initial appeared in ClinVar, as well as day this SCV was previous updated in ClinVar.

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The amount of variants in ClinVar for this gene, which include lesser variants throughout the gene and larger CNVs that overlap or fully incorporate the gene.

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Stars depict the overview standing, or the level of evaluate supporting the submitted (SCV) history. This price is calculated by NCBI based upon knowledge through the submitter.